Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii
نویسندگان
چکیده
منابع مشابه
Is Cryptococcus gattii a Primary Pathogen?
The two etiologic agents of cryptococcal meningoencephalitis, Cryptococcus neoformans and C. gattii, have been commonly designated as either an opportunistic pathogen for the first species or as a primary pathogen for the second species. Such a distinction has been based on epidemiological findings that the majority of patients presenting meningoencephalitis caused by C. neoformans are immunoco...
متن کاملAncient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest
Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate ...
متن کاملNitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.
Proper regulation of metabolism is essential to maximizing fitness of organisms in their chosen environmental niche. Nitrogen metabolite repression is an example of a regulatory mechanism in fungi that enables preferential utilization of easily assimilated nitrogen sources, such as ammonium, to conserve resources. Here we provide genetic, transcriptional, and phenotypic evidence of nitrogen met...
متن کاملSystematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans
The fungus Cryptococcus neoformans is a leading cause of mortality and morbidity among HIV-infected individuals. We utilized the completed genome sequence and optimized methods for homologous DNA replacement using high-velocity particle bombardment to engineer 1201 gene knockout mutants. We screened this resource in vivo for proliferation in murine lung tissue and in vitro for three well-recogn...
متن کاملCryptococcus gattii in the United States: clinical aspects of infection with an emerging pathogen.
BACKGROUND Cryptococcus gattii (Cg) has caused increasing infections in the US Pacific Northwest (PNW) since 2004. We describe this outbreak and compare clinical aspects of infection in the United States among patients infected with different Cg genotypes. METHODS Beginning in 2005, PNW state health departments conducted retrospective and prospective passive surveillance for Cg infections, in...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-03991-6